All famous Female Stars on stage are in reality young men, pre-pubertary boys. Their opposite gender Li(f)e starts at birth. Besides food, there are testosterone blocker and synthetic hormones.

Hormone Therapy does not change the bone structure.
Changes take place over years. 

Males that take estrogen have to stop the intake around age 30 to prevent blood clots. The testosterone surge in their body then launches puberty. This is why MTF age poorly.

Melinda Gates: BEFORE and AFTER puberty

After puberty the typical male sex characteristics appear. Their skull becomes larger, their neck thickens, the pores in their skin become larger.  

ESTROGEN

https://transcare.ucsf.edu/article/information-estrogen-hormone-therapy

Besides the physical effects, some of which are irreversible, even after stopping the intake of hormones, there are of course psychological effects !

TESTOSTERONE 

Listen to a female voice change on testosterone over 38 weeks. This is irreversible !

https://transcare.ucsf.edu/article/information-testosterone-hormone-therapy